Systematic analysis on the GSTM1 null phenotype and prostate cancer risk in Chinese people.

OBJECTIVE Glutathione S-transferase M 1 (GSTM1) is implicated as a risk factor for prostate cancer. However, this issue is not clear in Chinese population. This systemic analysis was conducted to evaluate the effect of GSTM1 null genotypes on prostate cancer risk in Chinese. METHODS Published studies investigating the associations between GSTM1 null genotypes and the risk of prostate cancer in China were identified by using a predefined search strategy. Main statisticals were pooled and estimated according to the primarily reported data. RESULTS The prevalence of the GSTM1 null genotype was higher in prostate cancer patients than in controls, with significance. CONCLUSION The GSTM1 null genotypes is associated with increased risk of prostate cancer in Chinese.